John O'Shea is set to come in, but Cristiano Ronaldo may be rested. United will have Carlos Tevez and Anderson back from international duty, although Michael Carrick and Owen Hargreaves are still missing.
And Sir Alex Ferguson may rest Ronaldo as he wants him to fully recover from a summer ankle operation.
Evra tweaked a hamstring during Saturday's win over West Bromich Albion.
UEFA Champions League, Group E
Line-up for this Tuesday:
Van der Sar, Kuszczak, Brown, Neville, R. Da Silva, Ferdinand, Vidic, Evans, O'Shea, Ronaldo, Nani, Fletcher, Anderson, Giggs, Gibson, Park, Tevez, Berbatov, Rooney, Manucho.
Venue: Old Trafford
Date: Tuesday, 21 October 2008
Kick-off: 19:45 BST
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